Pharmacodynamic modelling approaches in the setting of suboptimal drug adherence

Introduction. Suboptimal adherence may bias pharmacokinetic (PK) parameter estimates.1 Rather than conditioning the PD response on the model predicted PK response, an alternative approach is to fit a kinetic-pharmacodynamic (KPD) model in which the PK data are excluded from the analysis. KPD models may be an advantage in such scenarios because the KPD analysis allows […]