Background: The pharmacokinetics of many drugs are said to be predictable. This is often used to imply the ease of dosing or dose-adjustments. However, predictability requires both accuracy (lack of bias) and precision (reproducibility). In the context of pharmacokinetics, precision refers to the ability to achieve a specified target concentration in different individuals. Precision is […]
Tag Archives | 2015
Characterising the transmission dynamics of Acinetobacter baumannii in intensive care units using hidden Markov models
December 16, 2014
Authors Tan N. Doan (1), David C. M. Kong (1), Caroline Marshall (2,3), Carl M. J. Kirkpatrick (1), Emma S. McBryde (2,3)
Affiliations 1. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia; 2. Victorian Infectious Diseases Service at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; 3. Department of Medicine, University of Melbourne, Melbourne, Australia
Presentation type Oral
Presenters Tan Doan
Background: Little is known about the transmission dynamics of Acinetobacter baumannii in hospitals. In the absence of comprehensive epidemiological data, mathematical modelling is an attractive approach to understanding transmission process. The statistical challenge in estimating transmission parameters from infection data arises from the fact that most patients are colonised asymptomatically and therefore the transmission process […]
Model-based estimation of anticholinergic burden
December 15, 2014
Authors Mohammed S Salahudeen (1), Prasad S Nishtala (1), Stephen B Duffull (1)
Affiliations 1. University of Otago, Dunedin, New Zealand
Presentation type Oral
Presenters Mohammed S Salahudeen
Background: Older people exposed to medicines with anticholinergic properties are at an increased risk of experiencing adverse events. Anticholinergic burden refers to exposure to 1 or more medicines with anticholinergic activity. Studies have reported anticholinergic burden to be a strong predictor of cognitive and physical impairment in older people1. Background work in this area has […]