Aim: The objective of this study was to evaluate the pharmacokinetic properties of vancomycin in orthopaedic patients during routine clinical care using a non-linear mixed effects modelling approach. Methods: A two-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration data (n = 1198 points) obtained retrospectively from routine therapeutic drug monitoring records […]

Yoke-Lin Lo
- PAGANZ Inc Society Member
- International Medical University
Author Archive | Yoke-Lin Lo
Population pharmacokinetics of midazolam in critically ill septic patients
January 13, 2011
Authors Yoke-Lin Lo, Cheng-Cheng Tan, Toong-Chow Lee, Bruce G. Charles
Affiliations (1) University of Malaya, Malaysia, (2) Sultanah Aminah Hospital, Malaysia, (3) University of Queensland, Australia
Presentation type Oral
The aim of this study is to determine the pharmacokinetic parameters of midazolam (MDZ) and its active metabolites, namely 1-hydroxymidazolam (1-OH-MDZ) and 1-hydroxymidazolam glucuronide conjugate (1-OH-MDZG) in patients with various degrees of severity of sepsis syndrome. A 6-compartment disposition model with combined intermittent oral administration and continuous intravenous infusion with first-order elimination was used. The […]
Population Pharmacokinetics of Vancomycin in Premature Malaysian Neonates: Identification of Predictors for Dosing Determination in the First Month of Life
December 23, 2009
Authors Yoke-Lin Lo, John G. Coen van Hasselt, Siow-Chin Heng, Chin-Thean Lim, Toong-Chow Lee, Bruce Charles
Affiliations University of Queensland, University of Malaya
Presentation type Poster
Background: Nothing is known of the pharmacokinetics of vancomycin in premature Malaysian infants during the first month of life. Knowledge of the factors which affect the fate of vancomycin in these infants could lead to improved dosage regimens for this antibiotic. Methods: A one-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration […]
Population Pharmacokinetics Of Gentamicin In Very Premature Neonates
January 22, 2008
Authors Yoke-Lin Lo (1,2), Toong-Chow Lee (3), Chin-Theam Lim (4), Bruce Charles (2)
Affiliations (1) Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia, (2) School of Pharmacy, University of Queensland, Australia, (3) lnfo Kinetics Pty. Ltd. Malaysia, (4) Department of Paediatrics, Faculty of Medicine, University of Malaya, Malaysia
Presentation type Oral
Gentamicin in combination with benzylpenicillin, is widely used as empiric treatment in early onset neonatal sepsis. The aim of this study is to explore influence of potential covariates on the pharmacokinetic parameters of gentamicin in very premature neonates. A population pharmacokinetic model was developed using NONMEM V (version 1.1). Serum gentamicin concentrations retrospectively collected from […]
Population Pharmacokinetics of Amikacin in Very Premature Malaysian Neonates
January 17, 2007
Authors Lo, YL, Charles, B, Lee, TC, Lim, CT
Affiliations Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia
Presentation type Oral
Background: Amikaicn is an aminoglycoside used in the treatment of early onset neonatal sepsis. Nephrotoxicity and ototoxicty induced by aminoglycosides are closely associated with the duration of treatment and the high plasma peak or trough levels. Therapeutic drug monitoring of amikacin has routinely been carried out in neonatal intensive units. Aim: To characterize the population pharmacokinetic parameters […]