Population pharmacokinetics of vancomycin in orthopaedic patients

Aim: The objective of this study was to evaluate the pharmacokinetic properties of vancomycin in orthopaedic patients during routine clinical care using a non-linear mixed effects modelling approach. Methods: A two-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration data (n = 1198 points) obtained retrospectively from routine therapeutic drug monitoring records […]

Population pharmacokinetics of midazolam in critically ill septic patients

The aim of this study is to determine the pharmacokinetic parameters of midazolam (MDZ) and its active metabolites, namely 1-hydroxymidazolam (1-OH-MDZ) and 1-hydroxymidazolam glucuronide conjugate (1-OH-MDZG) in patients with various degrees of severity of sepsis syndrome. A 6-compartment disposition model with combined intermittent oral administration and continuous intravenous infusion with first-order elimination was used. The […]

Population Pharmacokinetics of Vancomycin in Premature Malaysian Neonates: Identification of Predictors for Dosing Determination in the First Month of Life

Background: Nothing is known of the pharmacokinetics of vancomycin in premature Malaysian infants during the first month of life. Knowledge of the factors which affect the fate of vancomycin in these infants could lead to improved dosage regimens for this antibiotic. Methods: A one-compartment infusion model with first-order elimination was fitted to serum vancomycin concentration […]

Population Pharmacokinetics Of Gentamicin In Very Premature Neonates

Gentamicin in combination with benzylpenicillin, is widely used as empiric treatment in early onset neonatal sepsis. The aim of this study is to explore influence of potential covariates on the pharmacokinetic parameters of gentamicin in very premature neonates. A population pharmacokinetic model was developed using NONMEM V (version 1.1). Serum gentamicin concentrations retrospectively collected from […]

Population Pharmacokinetics of Amikacin in Very Premature Malaysian Neonates

Background: Amikaicn is an aminoglycoside used in the treatment of early onset neonatal sepsis. Nephrotoxicity and ototoxicty induced by aminoglycosides are closely associated with the duration of treatment and the high plasma peak or trough levels. Therapeutic drug monitoring of amikacin has routinely been carried out in neonatal intensive units. Aim: To characterize the population pharmacokinetic parameters […]