Investigating myotoxicity following red-bellied black snake envenomation

Background: Red-bellied black snake (RBBS; Pseudechis porphyriacus) envenomation can cause systemic myotoxicity, which is characterised by elevated serum creatine kinase (CK) concentrations greater than 1,000 U/L. An understanding of the time course of venom concentrations and serum CK is useful for developing treatment plans for envenomed patients. Aims: This study aims to 1) determine whether […]

Investigating the pharmacokinetics of snake venom – a cocktail of toxins

Background: Snake venom is a mixture of protein-toxins, which can cause a range of biological effects. The protein components in snake venom have molecular sizes ranging from 4 kDa to 150 kDa and are expected to exhibit different pharmacokinetics (PK) profiles. Therefore, the phenomenological appearance of plasma snake venom concentrations is governed by the combination of […]

Meta-analysis of snake venom pharmacokinetics in humans

Background: Snake envenomation can result in devastating local and systemic effects, which requires hospitalisation, and on occasion permanent disabilities and fatality in severe cases [1]. The management of snake envenomation involves supportive treatment and administration of snake specific antivenoms to neutralise free venom and prevent further envenomation. The knowledge of snake venom pharmacokinetics in humans […]