Introduction: Renal dose adjustment generally assumes a linear relationship between renal drug clearance (CLR) and glomerular filtration rate (GFR). The theory underpinning this practice is the intact nephron hypothesis (INH) [1]. Studies designed to test INH do not generally consider optimisation of design factors like sampling time, values of GFR, sample size, etc. [2]. The […]
Sudeep Pradhan
- PAGANZ Inc Society Member
- Parexel International
Author Archive | Sudeep Pradhan
Evaluation of study designs to test the intact nephron hypothesis
January 6, 2019
Authors Sudeep Pradhan, Daniel F.B. Wright, Stephen B. Duffull
Affiliations University of Otago
Presentation type Oral
Presenters Sudeep Pradhan
Introduction: Renal dose adjustment generally assumes a linear relationship between renal drug clearance (CLR) and glomerular filtration rate (GFR). The theory underpinning this practice is the Intact Nephron Hypothesis (INH) [1]. A recent review by our group suggested that the INH may not be a suitable general model for renal drug clearance, particularly for drugs that […]
Study designs for renal drug studies
January 24, 2018
Authors Sudeep Pradhan (1), Daniel F.B. Wright (1), Stephen B. Duffull (1)
Affiliations 1. University of Otago
Presentation type Oral
Presenters Sudeep Pradhan
Introduction: Renal dose adjustment generally assumes a linear relationship between renal drug clearance and glomerular filtration rate (GFR). The theory underpinning this practice is the Intact Nephron Hypothesis (INH) [1], which assumes that nephrons are either completely functional (intact) or completely non-functional. There is a growing body of evidence to suggest that a non-linear relationship […]