Introduction: Renal dose adjustment generally assumes a linear relationship between renal drug clearance (CLR) and glomerular filtration rate (GFR). The theory underpinning this practice is the Intact Nephron Hypothesis (INH) [1]. A recent review by our group suggested that the INH may not be a suitable general model for renal drug clearance, particularly for drugs that […]
Sudeep Pradhan
- PAGANZ Inc Society Member
- University of Otago
Author Archive | Sudeep Pradhan
Study designs for renal drug studies
January 24, 2018
Authors Sudeep Pradhan (1), Daniel F.B. Wright (1), Stephen B. Duffull (1)
Affiliations 1. University of Otago
Presentation type Oral
Presenters Sudeep Pradhan
Introduction: Renal dose adjustment generally assumes a linear relationship between renal drug clearance and glomerular filtration rate (GFR). The theory underpinning this practice is the Intact Nephron Hypothesis (INH) [1], which assumes that nephrons are either completely functional (intact) or completely non-functional. There is a growing body of evidence to suggest that a non-linear relationship […]