Author: Samantha Nelis

Application of Population Modelling to Improve the Estimation of Drug Withdrawal Times in Racehorses

Samantha Nelis (1,2), Carl Kirkpatrick (3), Stefanie Hennig (2), Lisa Nissen (2) and Nick Shaw (2).
(1) Queensland Government Racing Science Centre, (2) ) School of Pharmacy, University of Queensland; Australian Centre of Pharmacometrics (3) Monash University

Background: The rules of racing state that an animal may not be treated on the day of a race and must be presented at the racetrack as “drug-free”. Drug treatment needs to be stopped prior to ensure compliance with these rules. Many factors influence the drug withdrawal time including, but not limited to, the pharmacokinetics […]

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Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically-Ill Patients from a Multi-Center Study Provide Dosing Recommendations for Patients

S. M. Garonzik (1), J. Li (2), V. Thamlikitkul (3), D. L. Paterson (4), S. Shoham (5), J. Jacob (6), F. P. Silveira (6), A. Forrest (1), R. L Nation (2)
(1) School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, (2) Facility for Anti-infective Drug Development and Innovation, Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia , (3) Division of Infectious Diseases and Tropical Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, (4) The University of Queensland Center for Clinical Research, Royal Brisbane and Women

With increasing clinical emergence of multidrug-resistant Gram-negative pathogens and the paucity of new agents to combat these infections, colistin (administered as its inactive prodrug colistin methanesulfonate (CMS)) has re-emerged as a treatment option especially in critically-ill patients. Previously, there has been a dearth of pharmacokinetic (PK) data available to guide dosing in critically-ill patients including […]

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