Aims: Augmented renal clearance (ARC) in critically-ill patients can result in suboptimal drug exposures and potential treatment failure. This study aimed to design optimised combination dosage regimens of piperacillin and tobramycin against a Pseudomonas aeruginosa (Pa) clinical isolate and evaluate them in the hollow-fibre infection model (HFIM) for the pharmacokinetics of patients with ARC. Methods: […]
Author: Rajbharan Yadav
Mechanism-based PK/PD modelling approach to optimise combination dosage regimens against multidrug-resistant clinical isolates of Pseudomonas aeruginosa and in-vivo evaluation in a murine thigh infection model
Aims: Pseudomonas aeruginosa (Pa) is an opportunistic Gram-negative pathogen that is prevalent in bloodstream, wound and respiratory infections and has a high propensity to become multidrug-resistant. Our primary aim was to systematically evaluate synergistic killing and suppression of resistance of Pa by combinations of carbapenem plus aminoglycoside (AGS) antibiotics. Secondly, we sought to propose optimised […]
Mechanism-based pharmacodynamic modelling approach to optimise synergistic carbapenem plus aminoglycosides combinations to combat carbapenem-resistant Acinetobacter baumannii
Introduction. Antimicrobial resistance in Gram-negative bacteria is one of the three greatest threats to human health according to the WHO, EU and other organisations. Multi-drug resistant Gram-negative bacteria commonly cause serious infections with a high rate of mortality and high degree of morbidity. In the past, β-lactams and aminoglycosides were successfully used to treat susceptible […]