Author: Rajbharan Yadav

Mechanism-based modelling to optimise piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics

Rajbharan Yadav (1), Kate E. Rogers (1,2), Phillip J. Bergen (2), Jürgen B. Bulitta (3), Carl M. J. Kirkpatrick (2), Steven C. Wallis (4), David L. Paterson (4), Roger L. Nation (1), Jeffrey Lipman (5), Jason A. Roberts (4,5,6) and Cornelia B. Landersdorfer (1,2)
1. Drug Delivery, Disposition and Dynamics, 2. Centre for Medicine Use and Safety, Monash University, Parkville, VIC, Australia; 3. Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, FL, USA; 4. Centre for Clinical Research, 5. Royal Brisbane and Women’s Hospital, 6School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.

Aims: Augmented renal clearance (ARC) in critically-ill patients can result in suboptimal drug exposures and potential treatment failure. This study aimed to design optimised combination dosage regimens of piperacillin and tobramycin against a Pseudomonas aeruginosa (Pa) clinical isolate and evaluate them in the hollow-fibre infection model (HFIM) for the pharmacokinetics of patients with ARC. Methods: […]

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Mechanism-based PK/PD modelling approach to optimise combination dosage regimens against multidrug-resistant clinical isolates of Pseudomonas aeruginosa and in-vivo evaluation in a murine thigh infection model

Rajbharan Yadav (1), Jürgen B Bulitta (2), Jiping Wang (1), Roger L Nation (1), Cornelia B Landersdorfer (1)
1. Monash University, 2. University of Florida

Aims: Pseudomonas aeruginosa (Pa) is an opportunistic Gram-negative pathogen that is prevalent in bloodstream, wound and respiratory infections and has a high propensity to become multidrug-resistant. Our primary aim was to systematically evaluate synergistic killing and suppression of resistance of Pa by combinations of carbapenem plus aminoglycoside (AGS) antibiotics. Secondly, we sought to propose optimised […]

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Mechanism-based pharmacodynamic modelling approach to optimise synergistic carbapenem plus aminoglycosides combinations to combat carbapenem-resistant Acinetobacter baumannii

Rajbharan Yadav (1), Cornelia B Landersdorfer (1), Roger L Nation (1), John D Boyce (2), Jürgen B Bulitta (1)
1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, AUS, 2. Department of Microbiology, Monash University, Clayton, VIC, AUS

Introduction. Antimicrobial resistance in Gram-negative bacteria is one of the three greatest threats to human health according to the WHO, EU and other organisations. Multi-drug resistant Gram-negative bacteria commonly cause serious infections with a high rate of mortality and high degree of morbidity. In the past, β-lactams and aminoglycosides were successfully used to treat susceptible […]

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