Generalisation of T-optimality for discriminating between competing models – an application to paracetamol overdose

Background and objectives: The T-optimality criterion for model discrimination was introduced by Atkinson and Fedorov [1]. Application of this method required the condition that one of the competing models is correct. We term this criterion local T-optimality. In addition, T-optimal designs are generally not efficient for parameter estimation. The aims of current work are (1) to […]

Pharmacodynamics of venlafaxine in overdose

Background: Venlafaxine, a serotonin-noradrenalin reuptake inhibitor, appears to be more toxic in overdose than other newer antidepressants. Various studies have shown that there is an increased risk of seizures [1], a potential for cardiac toxicity [2] and a higher rate of fatalities [3] with venlafaxine overdose when compared to other antidepressants. A population pharmacokinetic (PK) analysis […]