Population Pharmacokinetic-Pharmacodynamic Modeling: When Modeling Meets Reality

Overview The pharmacokinetic and pharmacodynamic behaviors of many therapeutic agents have inherent complexities that require specialized modeling approaches in order to develop reliable, unbiased models.  Several commonly encountered cases will be presented, including data that has a preponderance of zero values, subjects whose pharmacodynamic trajectories are not predictable based on a structural model, and evaluating models […]