Diane Mould

Author Archive | Diane Mould

Population Pharmacokinetic-Pharmacodynamic Modeling: When Modeling Meets Reality

Overview The pharmacokinetic and pharmacodynamic behaviors of many therapeutic agents have inherent complexities that require specialized modeling approaches in order to develop reliable, unbiased models.¬†¬†Several commonly encountered cases will be presented, including data that has a preponderance of zero values, subjects whose pharmacodynamic trajectories are not predictable based on a structural model, and evaluating models […]

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