mohamed82008

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Analysis of Laplace Approximation for Pharmaceutical Nonlinear Mixed Effects Models

Laplace approximation and its various approximations are some of the most commonly used techniques in pharmaceutical nonlinear mixed effects modelling to marginalise the the random effects. Classically, only Gaussian random effects have been used with transformations applied after the fact. In this work, the Laplace approximation framework is mathematically analysed showing the theoretical soundness of […]

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