January 10, 2021
Authors Rachael Lawson1,2, Christine E. Staatz1, Christopher J Fraser3, Stefanie Hennig4,5.
Affiliations 1 The University of Queensland, School of Pharmacy, Brisbane, QLD, Australia. 2Queensland Children’s Hospital, Pharmacy Department, Brisbane, QLD, Australia. 3Queensland Children’s Hospital, Blood and Marrow Transplant Service, Brisbane, QLD, Australia. 4School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia. 5Certara, Inc., Princeton, New Jersey, USA.
Presentation type Oral
Presenters Rachael Lawson
Aims: To characterise the pharmacokinetics of busulfan in paediatrics and investigate changes in clearance over a 4-day treatment course of once daily intravenous therapy. Methods: A population pharmacokinetic model was developed using NONMEM®, based on first-order conditional estimation with interaction, in patients ≤18 years receiving once daily intravenous busulfan for haematopoietic stem cell transplant (HSCT) who had […]