Dose Correction for the Michaelis-Menten Approximation of the Target – mediated Drug Disposition Model

Objectives: The target-mediated drug disposition (TMDD) pharmacokinetic (PK) model applies to drugs exhibiting a clearance mechanism due to binding to their targets followed by internalization and degradation [1]. The Michaelis-Menten (M-M) the TMDD PK model was derived based on the rapid binding or quasi steady-state assumptions that implied that the target and drug binding and […]

Modeling of non-stationary RBC survival: Effect of erythropoietin on RBC mortality vs. production in rats.

An age-structured population model was applied to describe red blood cell (RBC) survival data in normal rats treated with recombinant human erythropoietin (rHuEPO). The primary purpose was to estimate the mean lifespan and age of RBCs from a study employing the random labeling technique. The second objective was to assess an impact on the RBC […]