Vancomycin dose optimisation in patients receiving high-flux haemodialysis

Background: Vancomycin is the most commonly prescribed intravenous (IV) antibiotic in the high-flux haemodialysis (HFHD) setting. The aim of this study was to develop a population pharmacokinetic (PK) model for vancomycin in HFHD to examine the probability of target attainment (PTA) of several dosing regimens of vancomycin to optimise dosing. Methods: Data were collected retrospectively […]

Impact of high-flux haemodialysis on the probability of target attainment for amoxycillin/clavulanic acid combination therapy

Introduction: High-flux dialysers are widely used in patients receiving haemodialysis due to increased permeability, solute flow and positive outcomes for patients. The clearances of small molecules, including amoxycillin (Amox)/clavulanic acid (Clav), are likely to increase during high-flux haemodialysis (HFHD). This will result in lower exposure and importantly, reduced efficacy. Objectives: This simulation study evaluates the […]