Background: Vancomycin is the most commonly prescribed intravenous (IV) antibiotic in the high-flux haemodialysis (HFHD) setting. The aim of this study was to develop a population pharmacokinetic (PK) model for vancomycin in HFHD to examine the probability of target attainment (PTA) of several dosing regimens of vancomycin to optimise dosing. Methods: Data were collected retrospectively […]
Katrina Hui
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Author Archive | Katrina Hui
Impact of high-flux haemodialysis on the probability of target attainment for amoxycillin/clavulanic acid combination therapy
January 16, 2015
Authors Katrina Hui(1), Kashyap Patel(1), David Kong (1), Michelle Nalder (2), Eugenie Pedagogos (3), Craig Nelson (4,5), Kirsty Buising (6) and Carl M Kirkpatrick (1)
Affiliations 1. Centre for Medicine Use and Safety, Monash University, 2. Department of Pharmacy, Royal Melbourne Hospital, 3. Department of Nephrology, Royal Melbourne Hospital, 4. Department of Nephrology, Western Health, 5. North West Academic Centre, University of Melbourne, 6. Victorian Infectious Diseases Service, Royal Melbourne Hospital
Presentation type Oral
Presenters Katrina Hui
Introduction: High-flux dialysers are widely used in patients receiving haemodialysis due to increased permeability, solute flow and positive outcomes for patients. The clearances of small molecules, including amoxycillin (Amox)/clavulanic acid (Clav), are likely to increase during high-flux haemodialysis (HFHD). This will result in lower exposure and importantly, reduced efficacy. Objectives: This simulation study evaluates the […]