A population pharmacokinetic model of SC insulin therapy for hyperglycemia during acute ischemic stroke among patients with pre-existing diabetes

Background: Regardless of pre-stroke diabetes status, patients admitted to the hospital for acute ischemic stroke are frequently observed to have elevated levels of blood glucose or hyperglycemia[1]. Hyperglycemia is associated with poor stroke outcomes[2]. Insulin therapy to achieve normoglycemia during the acute phase is associated with better clinical outcomes in other groups of critically ill […]