Navigation

James Morse

Author Archive | James Morse

A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults

January 10, 2021

Authors James D Morse (1), L Ignacio Cortinez (2), Brian J Anderson (3)
Affiliations 1 Department of Pharmacology & Clinical Pharmacology, University of Auckland, Park Road, Auckland 023, New Zealand. 2 Department of Anesthesiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile. 3 Department of Anaesthesiology, University of Auckland, Park Road, Auckland 1023, New Zealand.
Presentation type Poster
Presenters James Morse

A universal pharmacokinetic model was developed from pooled paediatric and adult data (40.6 postmenstrual weeks, 70.8 years, 3.1-152 kg). A three-compartment pharmacokinetic model with first-order elimination was superior to a two-compartment model to describe these pooled dexmedetomidine data. Population parameter estimates (population parameter variability %) were clearance (CL) 0.9 L/min/70 kg (36); intercompartmental clearances (Q2) […]

Continue Reading

Simulations to explore studies of propofol infusions in neonates and infants

January 15, 2019

Authors James D Morse (1), Jacqueline A Hannam (1), Brian J Anderson (2, 3)
Affiliations 1 Department of Pharmacology & Clinical Pharmacology, University of Auckland, New Zealand 2 Department of Anaesthesiology, University of Auckland, New Zealand 3 Department of Anaesthesia, Starship Children’s Hospital, Auckland, New Zealand
Presentation type Oral
Presenters James D Morse

There are no validated propofol infusion regimens in neonates and infants. Existing pharmacokinetic pharmacodynamic (PKPD) models do not include data from babies under the age of 1 year (1) making dosing in this population empirical, largely based on recommendations from Steur et al (2). Steur and colleagues recommend a bolus dose between 3-5 mg·kg-1 followed by infusion rates […]

Continue Reading