Introduction: Propofol is used for the induction and maintenance of anaesthesia in neonates, infants and children. Clearance is the pharmacokinetic parameter that determines maintenance infusion rates and clearance matures over the first years of life. Postmenstrual age (PMA) is typically used to quantify clearance maturation as it accounts for maturation that begins in utero. Maturation […]
James Morse
- PAGANZ Inc Society Member
- University of Auckland
Author Archive | James Morse
A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults
January 10, 2021
Authors James D Morse (1), L Ignacio Cortinez (2), Brian J Anderson (3)
Affiliations 1 Department of Pharmacology & Clinical Pharmacology, University of Auckland, Park Road, Auckland 023, New Zealand. 2 Department of Anesthesiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile 8331150, Chile. 3 Department of Anaesthesiology, University of Auckland, Park Road, Auckland 1023, New Zealand.
Presentation type Poster
Presenters James Morse
Attachments
A universal pharmacokinetic model was developed from pooled paediatric and adult data (40.6 postmenstrual weeks, 70.8 years, 3.1-152 kg). A three-compartment pharmacokinetic model with first-order elimination was superior to a two-compartment model to describe these pooled dexmedetomidine data. Population parameter estimates (population parameter variability %) were clearance (CL) 0.9 L/min/70 kg (36); intercompartmental clearances (Q2) […]
Simulations to explore studies of propofol infusions in neonates and infants
There are no validated propofol infusion regimens in neonates and infants. Existing pharmacokinetic pharmacodynamic (PKPD) models do not include data from babies under the age of 1 year (1) making dosing in this population empirical, largely based on recommendations from Steur et al (2). Steur and colleagues recommend a bolus dose between 3-5 mg·kg-1 followed by infusion rates […]