Background Extracellular bacterial metabolites have potential as markers of bacterial growth and resistance emergence, but have not been evaluated in dynamic in vitro studies. Aim To mathematically describe the relationship between bacterial response and extracellular metabolites in a HFIM. Methods An MDR hypermutable Pseudomonas aeruginosa CF clinical isolate was challenged with ceftolozane-tazobactam (C/T) simulating continuous […]
