Objectives: To (i) evaluate the suitability of a previous published population pharmacokinetic (PK) model of gentamicin in paediatric oncology patients1 in predicting drug exposure in non-oncology paediatric patients and (ii) investigate the relationship between PK parameters and covariates in both oncology and non-oncology paediatric patients using the full random-effect (FREM) covariate modelling approach.2 Methods: Data […]
Carolina Llanos
- The university of Queensland
Author Archive | Carolina Llanos
Improving gentamicin dosing in paediatric oncology patients
January 20, 2017
Authors Carolina Llanos-Paez, Christine Staatz, Stefanie Hennig
Affiliations School of Pharmacy, The University of Queensland, Brisbane, Australia
Presentation type Oral
Presenters Carolina Llanos-Paez
Objective: To develop and apply a population PK model of gentamicin in paediatric oncology patients in i) a utility function approach that balances the probability of efficacy against potential kidney damage related to gentamicin accumulation in the renal cortex and ii) a semi-mechanistic modelling approach to simulate bacterial killing over time under different doses; with […]