Background Carbapenem-resistant Enterobacterales, such as Klebsiella pneumoniae and Escherichia coli, are considered critical priority pathogens by the World Health Organization. These pathogens produce an extensive range of β-lactamases, including New Delhi metallo-β-lactamases (NDM) which render most β-lactams inactive. The newly approved β-lactam/β-lactamase inhibitor combination aztreonam/avibactam shows promise in treating these pathogens; however, penicillin-binding protein (PBP) […]
Author: Bonnie.Breen
Mechanism-based modelling of the response from hypermutable cystic fibrosis Pseudomonas aeruginosa isolates to inhaled aztreonam and tobramycin dosing regimens simulated in a dynamic biofilm model
Background Hypermutable, resistant and biofilm forming Pseudomonas aeruginosa proves challenging to treat in patients with cystic fibrosis (CF). Understanding biofilm killing and regrowth is important for the selection of effective antibiotic dosing regimens. Aim To develop a mechanism-based model (MBM) which characterises the time-course of planktonic and biofilm bacteria in response to aztreonam and tobramycin […]