Pharmacokinetic modelling of enterohepatic circulation of mycophenolic acid in Malaysian lupus nephritis patients

Introduction Mycophenolic acid (MPA) is an immunosuppressant agent which is increasingly be used in treatment of lupus nephritis patients. Currently it is given as a fixed dose without drug concentration monitoring, however it is likely patients would benefit from more individualised treatment. The objective of this current study is to develop a population pharmacokinetic model […]

A Review of Population Pharmacokinetic and Pharmacodynamic Studies of Mycophenolate in Autoimmune Disease Patients

Introduction: Mycophenolic acid (MPA), the active drug moiety of mycophenolate, is a potent immunosuppressant agent, which is increasingly being used in the treatment of patients with various autoimmune diseases. Despite the accumulation of promising clinical data on the benefits of mycophenolate in autoimmune diseases, there is a relative lack of data on its pharmacokinetics and […]