• University of Otago

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Quantifying the Dose-Response of Unfractionated Heparin Using a System Pharmacology Model of Coagulation

Introduction:¬†Unfractionated heparin (UFH) is commonly used in the treatment and prevention of a variety of thromboembolic disorders. Its short duration of action and reversibility of its effect with the use of protamine sulphate make it the agent of choice in acute settings such as cardiac surgery. However, optimal dosing of UFH remains challenging partly due […]

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