Introduction Assurance of mass balance is a critical part of pharmacometric model formulation (i.e. model creation and coding). In many cases, for simple mamillary compartmental models this can be assessed informally. However, in more complicated models (e.g. physiologically based models) the proof of mass balance can be more complicated. A method to evaluate mass balance […]
Tag Archives | 2022
A PBPK model for the clearance of nicotine and cotinine in pregnant women
January 21, 2022
Authors Harvey Ho
Affiliations Auckland Bioengineering Institute, The University of Auckland
Presentation type Oral
Presenters Harvey Ho
Active or passive maternal smoking causes many adverse effects on fetuses. Pregnancy-related physiologically based pharmacokinetic (p-PBPK) models could help interpret nicotine and its major metabolite cotinine‘s absorption, disposition, metabolism, and excretion (ADME) in pregnant women. This talk presents a p-PBPK model and its simulations for nicotine and cotinine. The maternal-placental-fetal compartments of the p-PBPK model contain […]
Finding the unknown parameters of a viral kinetics model of Covid-19 with immune response
January 21, 2022
Authors Angela (Sunggyeol) Jeong, Harvey Ho
Affiliations University of Auckland
Presentation type Poster
Presenters Angela (Sunggyeol) Jeong
The global pandemic caused by the outbreak of Covid-19 (SARS-CoV-2) remains to be an unsolved issue worldwide and has caused major uncertainties in our lives. This work models the viral kinetics of Covid-19, where the replication and elimination of the virus can be modelled using a system of ordinary differential equations (ODE). The unknown parameters […]
Time Course of Procalcitonin – Imputation of Missing Clock Times
January 21, 2022
Authors Abigail Bokor, Jacqueline Hannam, Nick Holford
Affiliations Department of Pharmacology and Clinical Pharmacology, University of Auckland
Presentation type Oral
Presenters Abigail Bokor
Background: Concentrations of endogenous procalcitonin (PCT) increase within hours of infection, and after events such as birth and surgery [1]. Determining the natural history of procalcitonin may help identify abnormal increases indicative of infection. However, in the dataset only the date of observations are recorded without the clock times [2]. If clock times are unavailable, […]
Open-Source Software for Vancomycin Therapeutic Drug Management in a Vietnamese hospital
January 21, 2022
Authors Hai L.B (1), Long Tr.T (1,2), Minh Vu D.A (1), Son Ng.T.(1) , Thuy Ng.T.T (1), Hai Ng.T (1), Lien Ng.T.B (2), Hanh Vu.B (2), Dua Ng.T (2),Huong Ng.T.L (1,*),
Affiliations 1. Hanoi University of Pharmacy, 2. Saint Paul Hospital, *. Corresponding author
Presentation type Poster
Presenters Hai Le Ba
Introductions: This study aims to assess and identify a suitable population pharmacokinetic (POP PK) model for vancomycin using concentration data from Vietnamese patients. The proper POP PK model was then utilized to construct a Bayesian tool to improve the quality of TDM service in Vietnam. Methods: Reviewing literature in Pubmed and the sites of available […]
Last-mile delivery: a reference plot to help non-pharmacometricians interpret population pharmacokinetics results
January 21, 2022
Authors Qingfeng He, Xiaoqiang Xiang, Weimin Cai, Xiao Zhu
Affiliations Fudan University
Presentation type Oral
Presenters Qingfeng He
BACKGROUND: Although pharmacometricians have put great efforts into transitioning the modeling results via simulations to facilitate the appropriate dosing, there is still a knowledge gap for frontline practitioners to understand the raw results from population pharmacokinetics (PopPK) analysis and subsequently make a meaningful interpretation to guide clinical practice. A practical tool is warranted to fill […]
In silico modelling for transplacental transfer of morphine in an ex vivo human cotyledon perfusion system
January 21, 2022
Authors Shengjie Zhang, Harvey Ho
Affiliations Auckland Bioengineering Institute, University of Auckland
Presentation type Poster
Presenters Shengjie (Sherry) Zhang
Transplacental properties of drugs are important for the well-being of fetuses. However, in vivo data on the transplacental effects of most drugs are rare due to ethical issues and technical challenges. Hence, ex vivo placenta cotyledon perfusion experiments have been used to investigate the transplacental properties since the 1960s. Recently there have been some efforts […]
A parametric repeated time-to-event modelling of recurrent ischemic stroke after index stroke among patients with diabetes mellitus
January 21, 2022
Authors Marwa Elsaeed Elhefnawy1, Sabariah Noor Harun1, Teo Leykhim2, Balamurugan Tangiisuran3, Hadzliana Zainal1, Irene Looi4, Norsima Sidek5, Zariah Abdul Aziz5, Siti Maisharah Sheikh Ghadzi1
Affiliations 1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, 11800 USM, Malaysia; 2 Clinical Research Center, Hospital Pulau Pinang, Malaysia; 3 National Poison Centre, Universiti Sains Malaysia, Penang, 11800 USM, Malaysia; 4 Clinical Research Center, Hospital Seberang Jaya, Malaysia; 5 Clinical Research Centre, Hospital Sultanah Nur Zahirah, Terengganu, Malaysia
Presentation type Oral
Presenters Marwa Elsaeed Elhefnawy
Objectives: Diabetes (DM) is associated with an increased risk of recurrent ischemic stroke (IS). A temporal description of an increased or decreased risk of recurrent IS among diabetic patients is not fully established. This study aimed to investigate the repeated time-to-event of recurrent IS after the index IS among patients with diabetes using a parametric […]
Patient-reported outcomes predict survival and adverse events following anticancer medicines initiation
January 21, 2022
Authors Natansh D Modi1, Nicolas O Danell1, Riley NA Perry1, Ahmad Y Abuhelwa1, Akash Rathod1, Sarah Badaoui1, Ross A McKinnon1, Mark Haseloff1, Adel Shahnam2, Sandra M Swain3, Manfred Welslau4, Michael J Sorich1, and Ashley M Hopkins1
Affiliations 1. College of Medicine and Public Health, Flinders University, South Australia, Australia. 2. Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia. 3. University of Georgetown Medical Center, Washington DC, USA. 4. Onkologie Aschaffenburg, Aschaffenburg, Germany
Presentation type Oral
Presenters Natansh D Modi
Background The prognostic value of patient-reported outcomes (PROs) has been minimally explored in advanced breast cancer, and their comparative prognostic performance against Eastern Cooperative Oncology Group performance status (ECOG PS) is largely unknown. Methods This study pooled individual participant data from clinical trials CLEOPATRA, EMILIA, and MARIANNE. Pre-treatment PRO associations with overall survival (OS), progression-free […]
Cefazolin pharmacokinetics and extent of device binding during cardiopulmonary bypass
January 21, 2022
Authors Conor J O’Hanlon (1), Jacqueline A Hannam (1), Brian J Anderson (2,3), Mark Greaves (3), Nick HG Holford (1)
Affiliations (1) Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. (2) Department of Anaesthesiology, University of Auckland, Auckland, New Zealand. (3) Department of Anaesthesia, Starship Children’s Hospital, Auckland, New Zealand.
Presentation type Oral
Presenters Conor O'Hanlon
Introduction: Cefazolin is administered routinely for antibiotic prophylaxis during cardiac surgery. However there is uncertainty in determining the correct dose due to the impact of critical illness and the cardiopulmonary bypass (CPB) machine on drug pharmacokinetics (PK). Aims: To quantify cefazolin adsorption to the CPB machine device and incorporate this into a population PK model […]