Program 2024

The Population Analysis Workshops (PAWs) and the PAGANZ Scientific Program will be held at Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Melbourne, Victoria, Australia. Please note, this meeting will be held at the Parkville campus, Monash University, not the Clayton Campus (which is 25 km away).

A detailed map of the Campus is available here.  When you arrive, please record your attendance and pick up a name badge at the registration desk.


Please note that this year we will be running both PAWS as Bring Your Own Device (BYOD)

Attendees of the Beginners PAWS will require their own working installation of NONMEM. Meeting attendees of both PAWS will be sent an email containing a link to all PAWS material, including access to NONMEM installation files and a temporary license associated with the meeting.

Social Events

Wednesday 14th February 2024
1830Student Social function: Where: The Oxford Scholar Hotel
Time: 6pm; with trivia starting at 6:30pm
Registration: https://forms.gle/RsuHuNDKeFY2JQS6A
Thursday 15th February, 2024
1800PAGANZ Dinner: Hotel Railway, 291 Albert St, Brunswick

Population Analysis Workshops (PAWs)

Beginners PAWs
Coordinator: Jacqueline Hannam (University of Auckland) and Shaun Kumar (Parexel)

Wednesday 14th February 2024

0830Registration and coffeeRegistration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1)
Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
0900Introduction to population methodsCossar Hall Tutorial Room 1, Ground Floor, Sissons Building (Bldg 1)
1000Morning tea
1030Hands on with NONMEM I: Residual variance models
1200Lunch
1300Building structural models
1500Afternoon tea
1530Building covariate models
1700Close

Thursday 15th February, 2023

0830Registration and coffeeRegistration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1)
Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
0900Hands on with NONMEM II: Covariate modelsCossar hall Tutorial Room 1, Ground Floor, Sissons Building (Bldg 1)
1000Morning tea
1030Critical appraisal and discussion
1200Lunch

Intermediate PAWs

Wednesday 14th February 2024

Pumas – 1 day

Coordinators: Mohamed Tarek, Pumas-AI.

For this workshop there will be a mixture of theory and hands on throughout the day.

0830Registration and coffeeRegistration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1)
Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
0900Setting up and introduction to Pumas cloudProfessional Practice Space (PPS) 1 and 2, First Floor, Scott Building (Bldg 2)
1000Morning tea
1030Pumas model building, data reading and estimation workflow
1200Lunch
1300Uncertainty quantification, simulation, and dose selection
1500Afternoon tea
1530Joint time to event and tumour size model
1700Close

Thursday 15th February, 2024

pyDarwin – 1/2 day

Coordinators: Mark Sale and Keith Nieforth, Certara

*Please note earlier start time

0800 Registration and coffeeRegistration: Sissons Foyer, Ground Floor, Sissons Building (Bldg 1)
Coffee: Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
0830*Overview of machine learning model selectionCollaborative Learning Space (CLS) 1-3, first floor, Scott Building (Bldg 2)
1000Morning tea
1030Hands on pyDarwin / Hands on Pirana with Darwin
1200Lunch
*Note earlier start time on Thursday 15th for Intermediate PAWS

PAGANZ Annual Scientific Meeting

Cossar Hall, Ground Floor, Sissons Building (Bldg 1)

Thursday 15th February, 2024

1300-1305 hWelcome to the PAGANZ Scientific meetingCornelia Landersdorfer
1305-1400 hISoP Lecture “How Pharmacometrics Accelerates Drug Development”Joga Gobburu, PhD, MBA, Director, Center for Translational Medicine University of Maryland School of Pharmacy
1400-1530 hFocus on Monash
Chair: Jacqueline Hannam
 
1400-1425Antibiotic PK/PD: from traditional indices towards model-informed personalised dosingCornelia Landersdorfer
1425-1450Incorporating ‘omics with PK/PD modelling: examples from in vitro hollow fibre infection modelsJess Tait
1450-1510Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophreniaSam Mostafa
1510-1530Anakinra Pilot – designing a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infantsCarl Kirkpatrick
1530-1600 hAfternoon tea + posters*Cossar Hall, Ground Floor, Sissons Building (Bldg 1)
Poster Presenters:
Hyo-jeong Ryu
Yu-Wei Lin
Ali Taheri
Austin Yue Feng Tan
Kevin Winardi
1600-1700 hPAGANZ Annual General MeetingJacqueline Hannam
1800 hPAGANZ Dinner: Hotel Railway, 291 Albert St, Brunswick
*Poster presenters will be available at the posters

Friday 16th February, 2024

0830-0900 hRegistration and coffee 
0900-1020 hFree oral presentations 1: Paediatrics
Chair: Dominika Fuhs
 
0900-0920 hSerum ganciclovir drug exposure in children receiving standard ganciclovir and valganciclovir dosingWenyu Yang  
0920-0940 hPharmacokinetics of tobramycin in children with cystic fibrosisKiera Harwood  
0940-1000 hAnalytical and non-analytical variation may lead to inappropriate antimicrobial dosing in neonates: an in silico studyThi Nguyen  
1000-1020 hPopulation Pharmacokinetics of Piperacillin-Tazobactam in Children’s Plasma and Cerebrospinal Fluid Across a Wide Spectrum of Childhood AgesWenyu Yang  
1020-1040 hMorning tea + posters 
1040-1200 hFree oral presentations 2:  Innovation and methodology
Chair: Shaun Kumar
 
1040-1100 hMethodologically appropriate evaluation of continuous BMI as a clinical predictor of chemoimmunotherapy efficacy in advanced non-small cell lung cancerLee Li
1100-1120 hMachine learning for enhanced survival prediction from tumour growth inhibition dataNatalie Parent
1120-1140 hPyDarwin Designer, a prototype, user friendly interface to pyDarwin for machine learning based model selection.Mark Sale
1140-1200 hA workflow for resolving model internal consistency in use-reuse settings (aka repairing unstable models)Stephen Duffull
1200-1220 hThe identifiability of a turnover model for allopurinol urate-lowering effectDan Wright
1220-1300 hLunch 
1300-1430 hFree oral presentations 3:
Chairs: Siobhonne Breen, Alice Terrill
 
1300-1320 hEvidence based optimal dosing of intravenous artesunate in children with severe falciparum malariaJulie Simpson
1320-1340 hMechanistic Modelling of Gastric pH-Dependent Drug-Drug InteractionsYan Yan Yeap
1340-1400 hMechanism-based modelling of the response from hypermutable cystic fibrosis Pseudomonas aeruginosa isolates to inhaled aztreonam and tobramycin dosing regimens simulated in a dynamic biofilm modelSiobhonne Breen
1400-1420 hA population pharmacokinetic model of SC insulin therapy for hyperglycemia during acute ischemic stroke among patients with pre-existing diabetesKaram Alali
1420-1440 hEffect of ciprofloxacin against Pseudomonas aeruginosa with different resistance mechanisms can be predicted with mechanism-based mathematical modelling where using PK/PD indices failsAlice Terrill
1440-1445 hStudent prize presentations and meeting closeCornelia Landersdorfer

With thanks to our sponsors!