Melbourne 2012 14th Annual Scientific Meeting

When: 
6 February 2012 - 8 February 2012

The 14th annual Population Approach Group in Australia and New Zealand (PAGANZ) meeting will be held in Melbourne, Australia from the Monday 6th to Wedneday 8th February. A population analysis workshop is included in the PAGANZ meeting.

Field:
Pharmacometrics, particularly regarding the design, analysis, interpretation and application of pharmacokinetic-pharmacodynamic studies.

Workshop Themes:

The 2012 beginners course will introduce the theory and practice of population modelling with NONMEM.

The intermediate course covers:

1. Transformations (1/2 day).

2. Clinical Trial Simulation (1/2 day).

3. Mechanism-based modelling of anti-infective agents (1/2 day)

Who should attend?
The PAGANZ meeting is the Australasian forum for scientists with a research and professional interest in the use of the population approach in pharmacokinetics and pharmacodynamics. A strong focus of this meeting is the application of population modelling and simulation techniques in the experimental, clinical and regulatory settings of drug development.

This meeting is designed for scientists and clinicians working in basic or clinical pharmacology research, pharmaceutical industry, regulatory bodies and postgraduate students. The meeting combines a hands on workshop given by leaders in the field and a scientific meeting giving researchers the opportunity to present and discuss their own work. This is an informal meeting and in the past has been very productive in helping and guiding researchers in this important area of pharmacology and drug development.

When:
The dates are Monday 6th- Wednesday 8th February 2012.

Getting there

Melbourne Airport is about 20kms south of the Monash University Parkville Campus. The fare from the airport to the city by taxi is about $60 (but depends on the time of day and traffic).  There are airport buses (Skybus) that will transport you from the airport to Southern Cross Station for $16.   You can either catch a tram, train, taxi or walk to your accommodation

Location:
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville  Melbourne, Victoria, Australia.

Please note, this meeting will be held a the Parkville campus, Monash University, not the Clayton Campus (which is 25 Kms away).

Program for Population Approach Workshops

Beginners (6th and 7th of Feburary)
 

Time Event Speaker
Monday (6th)    
0800-0830 Registration and Coffee  
0830-1030 Introduction to population methods Carl Kirkpatrick
1030-1100 Morning tea  
1100-1230 Hands on with NONMEM Kashyap Patel
1230-1330 Lunch  
1330-1530 Building Models Kashyap Patel
1530-1600 Afternoon Tea  
1600-1730 Covariate Models Carl Kirkpatrick
Tuesday (7th)    
0830-1030 Hands on with NONMEM II Kashyap Patel
1030-1100 Morning Tea  
1100-1230 Critical Appraisal and Discussion Carl Kirkpatrick/Kashyap Patel
1230-1330 Lunch  
1330 PAGANZ scientific program begins  

Intermediate Workshop (6th and 7th February)

Time Event Speaker
Monday (6th)    
0800-0830 Registration and Coffee  
0830-0900 Transformations - General Martin Bergstrand/Ron Keizer
0900-0945 Transformations of parameter distributions Martin Bergstrand/Ron Keizer
0945-1030 Parameter transformations (NONMEM-based) (Hands On) Martin Bergstrand/Ron Keizer
1030-1100 Morning tea  
1100-1145 Transformations of residual error distributions Martin Bergstrand/Ron Keizer
1145-1230 Residual Error transformations (NONMEM-based) (Hands On) Martin Bergstrand/Ron Keizer
1230-1330 Lunch  
1330-1415 What does Clinical Trial Simulation (CTS) try to do? Diane Mould
1415-1530 Using NONMEM for simulation (basic ideas) (Hands on) Nick Holford
1530-1600 Afternoon tea  
1600-1645 Using Pharsight Clinical Trial Simulator for CTS Nick Holford
1645-1730 Adaptive Simulation (Hands on) Diane Mould
Tuesday (7th)    
0830-0930 General principles of PK/PD Modelling of anti-infectives Alan Forrest/Jurgen Bulitta
0930-0945 Questions and Answers Alan Forrest/Jurgen Bulitta
0945-1030 Population PD modelling of bacterial growth and killing (Hands On) Alan Forrest/Jurgen Bulitta
1030-1100

Morning Tea

 
1100-1130 Mechanism-based modelling to maximize killing and prevent resistance Alan Forrest/Jurgen Bulitta
1130-1140 Questions and Answers Alan Forrest/Jurgen Bulitta
1140-1230 Modeling of bacterial regrowth due to emergence of resistance Alan Forrest/Jurgen Bulitta
1230-1330 Lunch  
1330 PAGANZ scientific program begins  

PAGANZ Program - All sessions will be held in Cossar Hall

Tuesday (7th) Focus on Melbourne - Carl Kirkpatrick (Chair) Speaker
1330-1335 Welcome from the Dean Bill Charman
1335-1405 Treatment of malaria: from drug discovery to optimisation of current therapies Julie Simpson
1405-1435 Sue Charman
1435-1505 Joel Tarning
1505-1530 Afternoon Tea  
  Free Oral Presentations- Bruce Green  (Chair)  
1530-1545 What is the best dosing regimen for allopurinol in patients with renal impairment Dan Wright
1545-1600 The pharmacokinetic profile of intravenous paracetamol in adult patients undergoing major adbominal surgery: a population analysis Katie Owens
1600-1615 Assessment of vancomycin dosing regimens in Intensive Care Unit patients with impaired renal function Ana Saiao
1615-1630 NextDose - A web based collaborative tool for dose individualisation Nick Holford
1630-1645 Evaluation of a Bayesian dose-individualisation method for enoxaparin Hesham Al-Sallami
1645-1700 A clinical trial incident: Why simple PK is sometimes not so simple

Areej Turkistani

     
1700-1730 Annual General Meeting  
     
Wednesday (8th)    
0800-0830 Registration and Coffee  
  Free Oral presentations- Stephen Duffull (Chair)  
0830-0845 Pharmacokinetics of high-dose methotrexate in children with cancer: a mechanism-based evaluation of clearance prediction Sarapee Hirankarn
0845-0900 What is the between cycle variability in methotrexate clearance? Nick Holford
0900-0915 Population pharmacokinetic analysis of ropivacaine and its metabolite PPX from pooled data in neonates, infants and children Leon Aarons
0915-0930 A model for maturation of milrinone clearance from prematurity to adulthood Anita Sumpter
0930-0945 Paracetamol and diclofenac additive effects after tonsillectomy Jacqui Hannam
0945-1000 A model for fat free mass in humans from very premature neonates to young adults Anita Sumpter
1000-1030 Morning tea  
  Focus on Melbourne  - Julie Simpson (Chair)  
1030-1050 Mechanism-based population modelling of dihydroartemisinin pharmacodynamics in murine malaria Kashyap Patel
1050-1110 Population modelling of vildagliptin as an inhibitor and substrate of dipeptidylpeptidase IV Cornelia Landersdorfer
1110-1130 Mechanism-based modelling of antibiotics to optimally cure patients and prevent resistance: progress, gaps and future perspectives

Jurgen Bulitta

  Free Oral Presentations - Nick Holford (chair)   
1130-1145 Pharmacokinetics of methotrexate in red blood cells Julia Korell
1145-1200 Development and application of a pharmacokinetic model for the glycation of albumin Stephen Duffull
1200-1215 Dose correction for the Michaelis-Menten approximation of the target-mediated drug disposition model Wojciech Krzyzanski
1215-1230 Mechanism-based modeling of antibiotic combinations Rachel Soon
     
1230-1330 Lunch - with Posters   
  Free Oral Presentations  -  Carl Kirkpatrick  (Chair)  
1330-1345 Adaptive PD-Optimal design of a pilot study for a clotting time test for enoxaparin Abhishek Gulati
1345-1400 Optimal designs for pharmacokinetic-pharmacodynamic studies of dihydroartemisinin following oral artesunate Kris Jamsen
1400-1415 A reduction in between subject variability is not required when adding a new covariate Chakradhar Lagishetty
1415-1430 Optimal designs for a pharmacominetic study of inhaled fentanyl in children Aaron Basing
     
1430-1500 Afternoon tea, Presentation of the Nick Holford student prize, close of meeting Carl Kirkpatrick (Chair)

Poster Presentations

Title Presenter
Which matrix is the most reliable to judge the inclusion of covariates: reduction of unexplained parameter variability, increase in explained parameter variability or change in OFV? Stefanie Hennig
Prediction correction: quick fix for VPC misdiagnosis in a tacrolimus popPK model Troels K Bergmann 

 

Acccomodation

Reccommended accomodation for the conference includes:

Vibe Hotel Carlton (2 mins walk)   http://www.vibehotels.com.au/default.asp?page=/vibe-locations/melbourne-hotels/vibe-hotel-carlton

Parade Inn (5 mins walk)  http://www.paradeinn.com.au/

Parkville Place Apartments (5-10 mins walk through park)  http://www.parkvilleplace.com.au/

Social Evening

The Social evening will be held at a venue close to the Faculty of Pharmacy and Pharmaceutical Sciences on the Tuesday evening (7th February) . 

Satellite Meeting

A basic PKPD course will be taught on Thursday 9th - Friday 10th February 2012, in Canberra, ACT, following the PAGANZ meeting .

Please visit the PKPD course website for details.